Bacteriophage Design
A constrained workflow for genome-scale phage design: generate candidates, filter them in silico, document the decisions, and hand a reviewable dossier to your biosafety committee.
Built around the published Evo 2 genome language model and the phage-design pipeline released by the Arc Institute. This is not a synthesis or clinical service.
Read the step-by-step tutorialFrom candidate generation to a reviewable dossier
The value is not a one-click genome. It is the filtering, documentation, and review layer around it.
1. Constrained design space
Choose a whitelisted bacterial host and a fixed reference genome. No arbitrary hosts, pathogens, or uploaded genomes.
2. Candidate generation
In the full pipeline, a genome language model proposes candidate genomes within the allowed design space. Evo 2 inference is designed to run in an isolated GPU worker.
3. In silico filtering
ORF prediction, genetic architecture, GC constraints, annotation, and similarity checks reduce the candidate set before any lab work.
4. Review dossier
Export FASTA or GenBank, review the audit trail, and generate a biosafety package for your institutional committee.
Guardrails by design
Phage design is dual-use. The product is built around review, not open-ended generation.
- Research-use only; no clinical or environmental release
- Host whitelist and fixed reference genomes
- Institutional verification (KYC) before any job
- Biosecurity screening before any synthesis handoff
- Synthesis blocked by default; exported files are watermarked
- Full audit trail of model, parameters, and filters
Phase 0 status
The current workbench runs a mock pipeline with synthetic, non-functional candidates. Institutional verification (KYC) is required before any job. Real Evo 2 inference and biosafety screening will be enabled only for approved institutions.
Evaluating phage design for your lab?
We are working with research teams on constrained, review-first workflows. Tell us about your host, panel, and biosafety process.